The Helix Aspersa is a brown garden snail and is an edible snail.
When the Helix Aspersa is injured or threatened, it secretes a mucin that repairs its skin and shell, and protects itself
from invaders or the environment. The serum we use is this special secretion that the Helix Aspersa produces to protect itself
and repair itself. The secretion can be obtained without harming the snail. Firt we fast the snails for 5 days, then we disinfect
them with a natural and harmless disinfectent. Next we gather the serum. The serum takes a lot of time to harvest.
Aspersa secretion has been used by numerous doctors to heal the skin of radiation and other burn victims.
contains, among other beneficial elements, GLYCOPROTEIN and COPPER PEPTIDES. Structural glycoproteins which occur in connective
tissue help bind together the fibers, cells, and ground substance of connective tissue. They may also help components of the
tissue bind to inorganic substances, such as calcium in bone.
Snail secretion contains, and helps to build extracellular
matrix. Collagens are, in most animals, the most abundant protein in the ECM (extracellular matrix). In fact, collagen is
the most abundant protein in the human body and accounts for 90% of bone matrix protein content. Collagens are present
in the ECM as fibrillar proteins and give structural support to resident cells. In simple terms, the extracellular matrix
is like a base or building block for cells. The ECM is also composed of elastins. Elastins, in contrast to collagens, give
elasticity to tissues, allowing them to stretch when needed and then return to their original state. This is useful in blood
vessels, the lungs, in skin, and the ligamentum nuchae, and these tissues contain high amounts of elastins.
APPLICATIONS OF EXTRACELLULAR MATRIX (taken from wikipedia here: http://en.wikipedia.org/wiki/Extracellular_matrix )
Matrix cells have been found to cause regrowth and healing of tissue. In human fetuses, for example, the extracellular matrix
works with stem cells to grow and regrow all parts of the human body, and fetuses can regrow anything that gets damaged in
the womb. Scientists have long believed that the matrix stops functioning after full development. It has been used in the
past to help horses heal torn ligaments, but it is being researched further as a device for tissue regeneration in humans.
terms of injury repair and tissue engineering, the extracellular matrix serves two main purposes. First, it prevents the immune
system from triggering from the injury and responding with inflammation and scar tissue. Next, it facilitates the surrounding
cells to repair the tissue instead of forming scar tissue.
For medical applications, the cells required are usually
extracted from pig bladders, an easily accessible and relatively unused source. It is currently being used regularly to treat
ulcers by closing the hole in the tissue that lines the stomach, but further research is currently being done by many universities
as well as the U.S. Government for wounded soldier applications. As of early 2007, testing was being carried out on a military
base in Texas. Scientists are using a powdered form on Iraq War veterans whose hands were damaged in the war.
ECM devices come from the bladder. Extracellular matrix coming from pig small intestine submucosa are being used to repair
"atrial septal defects" (ASD), "patent foramen ovale" (PFO) and inguinal hernia. After one year 95% of
the collagen ECM in these patches is replaced by the normal soft tissue of the heart.
The following quote comes from
this website: http://medgadget.com/2011/10/carotid-tissue-repair-device-gets-510k-nod-from-fda.html
"The use of
extracellular matrix materials in non-cardiovascular applications has established a significant foothold in soft tissue repair,
wound management and orthopedic applications. The safety of extracellular matrices has been well established in a number of
different clinical applications. The extracellular matrix has been studied extensively, with more than 500 published papers.
Since 1999, over a million patients worldwide have received an extracellular matrix implant"
HOW IT RELATES TO
THE USE OF HELIX ASPERSA IN SKINCARE
Helix Aspersa produces a secretion rich in proteins of high and low molecular
weight hyaluronic acid and antioxidants. The secretion of the snail has a double function when applied to human skin: on one
hand it is claimed to stimulate the formation of collagen, elastin and dermal components (ECM, much like the pig bladder in
the aforementioned references does), that repair the signs of photoaging and, second, is claimed to minimize the damage generated
by free radicals that are responsible for premature skin aging.
The website: http://odili.net/news/source/2011/nov/3/13.html
gave the following quote:
The study is titled "Molecular Basis for the regenerative Properties of a Secretion of
the Mollusk Cryptomphalus aspersa."
The researchers from Spain and United States found that the snail slime secretion
contains antioxidant superoxide dismutase (SOD) and Glutathione-S-Transferase Activity (GST) activities.
are substances that may protect cells from the damage caused by unstable molecules known as free radicals or reactive oxygen
species (ROS). SODs act as antioxidants and protect cellular components from being oxidized by reactive oxygen species.
addition the snail slime stimulates fibroblast proliferation and rearrangement of the actin cytoskeleton. Additional mechanisms
involved in its regenerative effect include the stimulation of extracellular matrix assembly and the regulation of metalloproteinase
activities. Together, these effects provide an array of molecular mechanisms underlying the secretion's induced cellular regeneration
and support its use in regeneration of wounded tissues," they wrote.
It has been shown that skin ageing is the
result of a complex process where genetics as well as chronological and environmental factors (particularly ultra violet UV
radiation) are involved. Skin aging manifests as wrinkles, diminished structural integrity and impaired wound healing due
to alterations in the remodeling process of the extracellular matrix (ECM). Several studies have shown that two of the basic
skin components, collagen and elastin, impart strength and their degeneration with the passing of time causes skin to become
fragile, and aged in appearance.
Indeed, many factors can affect skin regeneration. Researchers have demonstrated that
the presence of pathogens in the lesion may impair regeneration, and other factors such as reactive oxygen species can also
play a negative role in this process. In addition, dermal fibroblasts must proliferate and migrate into the injured tissue,
covering the lesion and manipulating the ECM ('matrix remodeling') to ensure scar formation and promote healing, a process
compromised by skin ageing.
The search of substances with regenerative properties has led many pharmaceutical companies
to develop extensive search programmes aimed to identify natural products that can induce skin regeneration or stimulate natural
In this regard, it has been noted that escargots (snails) perceive radiation, retract their orientation
organs, and secrete large amounts of mucous substances as a defensive response in order to protect themselves from harmful
In addition, escargots never suffer from skin infections, which directed researchers attention to the possibility
of using this secretion as a possible treatment of skin-compromising diseases.
An early study showed that a secretion
from the mollusk Cryptomphalus aspersa induces skin regeneration after wound healing impairment from acute radiodermatitis.
However, the molecular basis underlying this effect were unknown.
The researches responsible for this report evaluated
the regenerative properties of the secretion using multiple in vitro approaches. They found that it possesses antioxidant
capabilities and induces fibroblast proliferation. A complementary mechanism is provided by the fact that the secretion promotes
ECM (Extra Cellular Matrix) assembly, which is essential for wound healing and tissue plasticity.
The researchers wrote:
"Finally, the secretion inhibits Matrix Metalloproteinases (MMP) production, which limits the extent of the damage during
wounding and scar formation. MMP are naturally produced enzymes that help regulate the skin`s ability to repair itself. Together,
these mechanisms contribute to the observed beneficial effects of the snail secretion and support its use in regenerative
They added: "Furthermore, application of the secretion twice daily for three months also results
in a significant improvement of clinical and histopathological photoageing signs. However, the molecular foundations of the
beneficial effect of the secretion remained unknown. The cited report shows in vitro analysis of several possible contributions
to the physiological effect of the snail's secretion. First, it was found that the snail's secretion bear antioxidant activities
as well as free radical scavenging capability.
"The role of oxidation in wound healing is controversial, but there
is a clear correlation between enzymatic and non-enzymatic cutaneous antioxidants and its protection from ROS-mediated skin
damage induced by UV radiation. Indeed, UV radiation can decrease endogenous antioxidant levels and lead to increased damage.
In these cases, antioxidant compounds can modulate abnormal remodeling after trauma or prevent or reverse clinical signs associated
with photoaging secondary to ROS."
NOTE: THE STATEMENTS ABOVE HAVE NOT BEEN EVALUATED BY THE FDA. THIS PAGE IS
FOR INFORMATIONAL PURPOSES ONLY. OUR PRODUCTS ARE COSMETIC IN NATURE, AND ARE NOT INTENDED TO PREVENT, TREAT OR CURE